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ISBN10: 1260458369 | ISBN13: 9781260458367
ISBN10: 1260458369
ISBN13: 9781260458367
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The clearest, most concise coverage of one of the most complex topics in medicine—updated with the latest advances in the field Doody's Core Titles for 2023! Clinical Neurology, Eleventh Edition, provides a comprehensive overview of basic and clinical neurology in a concise, digestible format. It links clinical neuroscience to current approaches for accurately diagnosing and effectively treating neurologic disorders. Covering all the advances in molecular biology and genetics, this popular guide emphasizes history-taking and neurologic examination as the cornerstones of diagnosis. All information is thoroughly up-to-date and presented as a practice-oriented approach to neurology based on the patient's presenting symptoms or signs. Features: 350+ tables and figures Chapter outlines providing overview of each topic Treatment protocols reflecting the most recent advances in the field Step-by-step review of the neurologic examination
Chapter 1. NeurologicHistory & Examination
Neurologic examination ofsphincter function
Chapter 2. InvestigativeStudies
Neuromuscular imaging studies
Update on ultrasonography forneuromuscular diagnosis
Chapter 3. Coma
Introduction
Role of prefrontal cortex in consciousness
Causes of coma
Spontaneous intracranialhypotension as a cause of coma
Persistent vegetative state
New imaging insights intopersistent vegetative & minimally conscious states
Treatment of traumatic vegetative &minimally conscious states with amantadine
Chapter 4. ConfusionalStates
Drugs
Serotonin syndrome
Electrolyte disorders
Antidepressant-inducedhyponatremia
Endocrine & metabolic disorders
Mechanisms of impairedhypoglycemia sensing in treated diabetes
Nutritional disorders
Furosemide-induced thiaminedeficiency
Organ system failure
ICU delirium
Postoperative cognitivedysfunction
Meningitis, encephalitis & sepsis
Mechanism of N. meningitidis vascular spread
Dysregulated host inflammatoryresponse in tuberculous meningitis
CSF findings in HIV-infectedpatients with tuberculous meningitis
Tick-borne encephalitis & (re-emergent)yellow fever
Nipah virus encephalitis
Updated diagnostic testing forviral encephalitis
New recommendation on empiricaltreatment of toxoplasmosis in AIDS
Fexinidazole for treatment of Africantrypanosomiasis
Mechanism of meningeal invasion inleukemia
Chapter 5. Dementia& Amnestic Disorders
Introduction
Somatic neuronal mutations in aging and neurodegeneration
Differential diagnosis
Biomarker-based diagnostic algorithms for dementia syndromes
Neurodegenerativeproteinopathies
Tau folding in Alzheimer vs. Pickdisease
Tau-disrupted nucleocytoplasmictransport in Alzheimer disease pathogenesis
Contrasting mechanisms ofaggregate toxicity in neurodegeneration
Herpes simplex virus infection andAlzheimer disease
Inflammation in Alzheimer diseasepathogenesis
Meningeal lymphatics (glymphatics)in Alzheimer disease pathogenesis
Blood pressure and risk of Alzheimerdisease
Relation between epilepsy anddementia
Exercise training in dementia
Sex differences in Alzheimerdisease
Spatial navigation deficits asearly signs of Alzheimer disease
Subjective cognitive decline in relationto Alzheimer disease
Update on biomarkers for Alzheimerdisease
Concomitant neurodegenerativeproteinopathies
Update on clinical trials oftreatments for Alzheimer disease (eg, solanezumab, verubecestat)
Clinical and pathologicalcorrelates of primary progressive aphasia variants
New consensus guidelines fordiagnosis & treatment of dementia with Lewy bodies
Skin prions in Creutzfeldt-Jakobdisease infectivity and diagnosis
Other cerebral disorders
Shunting response to gait vs. dementia in normal pressurehydrocephalus
Normal pressure hydrocephalus vs.neurodegenerative ventriculomegaly
Mild traumatic brain injury & dementia
Systemic disorders
Subclinical hyperthyroidism &dementia
Pseudodementia
Features of memory impairment in depression
Amnestic syndromes
Update on antibody-mediatedencephalitis antigens & treatment
Chapter 6. Headache& Facial Pain
Migraine
Triptans, SSRIs & serotoninsyndrome
CGRP receptor-blocking monoclonalantibodies (eg, erenumab, fremanezumab)
Prochlorperazine plusdiphenhydramine vs. hydromorphone for IV migraine therapy
Vagus nerve
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