Casarett & Doull's Toxicology: The Basic Science of Poisons, 10e by Curtis D. Klaassen, 10th Edition

The landmark 10th edition of the gold-standard text on the science of poisons–updated to reflect the latest breakthroughs and developments

Casarett & Doull’s Toxicology: The Basic Science of Poisons provides readers with an unmatched foundation in modern toxicology, covering core principles, mechanisms, chemical-specific effects, and the critical modes of thinking that define the discipline. Thoroughly revised and updated, this tenth edition introduces two new chapters addressing the most pressing emerging topics in the field.

The text is divided into seven sections: 

• General Principles of Toxicology
• Disposition of Toxicants
• Non-Organ Directed Toxicity
• Target Organ Toxicity
• Toxic Agents
• Environmental Toxicology
• Applications of Toxicology 

New contributors cover the latest advances in toxicologic science
 
More than one-third of the chapters feature contributions from scientists new to the book, bringing diverse expertise and contemporary insight to every section.
This tenth edition explores key developments including apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptor function, gene regulation, signaling pathways, and protective and repair mechanisms—among many others.

Whether used as a comprehensive review or an authoritative reference, this trusted classic remains the most current, in-depth resource available for understanding how toxic substances affect biological systems—from the cellular level to whole-body responses.