The table of contents (below) will mirror the main text, both for completeness and ease of cross-referencing.
Historical Principles and Perspectives Toxicologic Misfortunes and Catastrophes in History PART A
THE GENERAL APPROACH TO THE PATIENT
Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes Principles of Managing the Acutely Poisoned or Overdosed Patient SC1. Principles of Antidote Stocking Decontamination Principles: Prevention of Gastrointestinal Absorption
SC2. Decontamination Principles: Prevention of Dermal, ophthalmic and inhalational Absorption
A1. Activated Charcoal
A2. Whole-Bowel Irrigation and Other Intestinal Evacuants
Principles and Techniques Applied to Enhance Elimination
Laboratory Principles Principles of Diagnostic Imaging Pharmacokinetic and Toxicokinetic Principles PART B
THE FUNDAMENTAL PRINCIPLES OF MEDICALTOXICOLOGY
SECTION I
BIOCHEMICAL AND MOLECULAR CONCEPTS
Chemical Principles
Biochemical and Metabolic Principles Fluid, Electrolyte, and Acid–Base Principles
Neurotransmitters and Neuromodulators
Withdrawal Principles
SECTION II
PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS
Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles Cardiologic Principles II: Hemodynamics
Dermatologic Principles
SC3. Transdermal Toxicology
Gastrointestinal Principles
Genitourinary Principles
Hematologic Principles
Hepatic Principles
Neurologic Principles Oncologic Principles
Ophthalmic Principles
Otolaryngologic Principles
Psychiatric Principles SC4. patient violence
Respiratory Principles
Thermoregulatory Principles
SECTION III
SPECIAL POPULATIONS
Reproductive and Perinatal Principles
Pediatric Principles
Geriatric Principles PART C
THE CLINICAL BASIS OF MEDICAL TOXICOLOGY
SECTION I
A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS
Acetaminophen
A3. N-Acetylcysteine
Colchicine, Podophyllin, and the Vinca Alkaloids
Nonsteroidal Antiinflammatory Drugs
Opioids
A4. Opioid antagonists
SC5. Internal Concealment of Xenobiotics
SC6. Harm Reduction for Opioid Overdose
Salicylates
A5. Sodium bicarbonate
B. Food, Diet, and Nutrition
Botulism
A6. botulinum antitoxin
Food Poisoning Dieting Xenobiotics and Regimens Athletic Performance Enhancers Essential Oils Plantand Animal-Derived Dietary Supplements Vitamins Iron
A7. deferoxamine
C. pharmaceuticals
Pharmaceutical Additives Antidiabetics and Hypoglycemics/Antiglycemics
A8. Dextrose(d-Glucose)
A9. octreotide
Antiepileptics
A10. l-carnitine
Antihistamines and Decongestants A11. physostigmine salicylate
Chemotherapeutics Methotrexate,5-Flourouracil, and Capecitabine
A12. folates :leucovorin (Folinic acid) and Folic Acid
A13. glucarpidase(carboxypeptidase g2)
A14. uridine triacetate
SC7. Inadvertent Intrathecal Administration of Xenobiotics
SC8. Extravasation of Chemotherapeutics
Antimigraine Medications Thyroidand Antithyroid Medications
D. Antimicrobials
Antibacterials, Antifungals, and Antivirals Antimalarials
Antituberculous Medications
A15. pyridoxine
E. Cardiopulmonary Medications
CASE STUDY 4
Antidysrhythmics
A16. Magnesium Sulfate
Antithrombotics
A17. Protein Complex Concentrate and Novel Antithrombotic Antidotes
A18. Vitamin k1
A19. protamine
β-Adrenergic Antagonists A20. Glucagon Calcium Channel Blockers A21. High-dose insulin (HDI)
Miscellaneous Antihypertensives and Pharmacologically Related Agents Cardioactive Steroids
A22. digoxin-specific antibody fragments
Methylxanthines and Selective β2-Adrenergic Agonists
F.ANESTHETICS AND RELATED MEDICATIONS
Local Anesthetics A23. lipid emulsion Inhalational Anesthetics
Neuromuscular Blockers A24. dantrolene sodium
G. Psychotropics
Antipsychotics
Cyclic Antidepressants
Serotonin Reuptake Inhibitors and Atypical Antidepressants Lithium
Monoamine Oxidase Inhibitors Sedative-Hypnotics A25. flumazenil
H. SUBSTANCES OF ABUSE
Amphetamines
Cannabinoids
Cocaine A26. Benzodiazepines Ethanol A27. Thiamine hydrochloride Ethanol Withdrawal
Disulfiram and Disulfiram-like Reactions Hallucinogens
γ-Hydroxybutyric Acid (γ-Hydroxybutyrate)
Inhalants Nicotine
Phencyclidine and Ketamine
I. Metals
Aluminum
Antimony
Arsenic A28. Dimercaprol (british anti-lewisite or bal) Bismuth
Cadmium
Cesium Chromium
Cobalt
Copper
Lead A29. succimer (2,3-dimercaptosuccinic acid)
A30. edetate calcium disodium (CaNa2EDTA)
Manganese
Mercury
Nickel
Selenium Silver Thallium A31. Prussian blue
Zinc
J. HOUSEHOLD PRODUCTS
Antiseptics, Disinfectants, and SterilantsCamphorand Moth Repellents
Caustics
Hydrofluoric Acid and Fluorides A32. Calcium
Hydrocarbons
Toxic Alcohols A33. fomepizole A34. ethanol SC9. Diethylene Glycol
K. PESTICIDES
Barium
Fumigants
Herbicides
Insecticides: Organic Phosphorus Compounds and Carbamates
A35. Atropine
A36. Pralidoxime
Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, Neonicitinoids and Insect Repellents Phosphorus
Sodium Monofluoroacetate and Fluoroacetamide Strychnine
L. Natural Toxins and Envenomations
Arthropod A37. antivenom: spiderA38. antivenom: scorpion Marine Envenomations
Mushrooms Plants
Native(US) Venomous Snakes and Lizards A39. antivenom: snakes (native [US] venomous [crotaline and elapid]) SC10. Exotic Nonnative Snake Envenomations
M. OCCUPATIONAL AND ENVIRONMENTAL TOXINS
CASE STUDY 11
Smoke Inhalation
Simple Asphyxiants and Pulmonary Irritants
Carbon Monoxide A40. hyperbaric oxygen
Cyanide and Hydrogen Sulfide
A41. hydroxocobalamin
A42. nitrites(sodium amyl) and sodium thiosulfate
Methemoglobin Inducers
A43. methyleneblue
Nanotoxicology
N. DISASTER PREPAREDNESS
Chemical Weapons
Biological Weapons
Radiation A44. Potassium iodide
A45. Pentetic acid or pentetate (zinc or calcium) trisodium (dtpa)
part D
POPULATION HEALTH
section 1
POISON CENTERS, HEALTH SYSTEMS, AND EPIDEMIOLOGY
Poison Prevention and Education Poison Centers and Poison Epidemiology Principles of Occupational Toxicology: Diagnosis and Control
Hazardous Materials Incident Response Risk Assessment and Risk Communication Medication Safety and Adverse Drug Events Drug Development, Adverse Drug Events, and Post-marketing Surveillance International Perspectives on Medical Toxicology
Principles of Epidemiology and Research Design Section II
LEGAL ASPECTS OF TOXICOLOGY
Risk Management and Legal Principles Medicolegal Interpretive Toxicology SC11. Assessment of Ethanol-Induced Impairment Postmortem Toxicology SC12. Organ Procurement from Poisoned Patients
