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Goldfrank's Clinical Manual of Toxicologic Emergencies, Second Edition https://www.mheducation.com/cover-images/Jpeg_400-high/1260474992.jpeg 2 2023 9781260474992 Derived from the definitive guide to medical toxicology, this hands-on companion provides accurate information for diagnosing and treating poisoned patients on the spot After more than a decade on the market, Goldfrank’s Toxicologic Emergencies has established itself as the go-to reference for medical toxicology—and this companion manual distills the most important information into a portable, easy-to-navigate resource. Goldfrank’s Manual of Toxicologic Emergencies distills critical information into short summaries and synopses, so you can use it to treat patients in clinical settings or for quick review of critical topics. Fully updated to ensure all information is completely current, this new edition is filled with tables, figures, images, and other visuals to make finding the right answers quick and easy. Each chapter is a direct distillation of the corresponding chapter in Goldfrank’s Toxicologic Emergencies. Whether you’re a medical toxicologist, pharmacist, physician, nurse practitioner, or student, Goldfrank’s Manual of Toxicologic Emergencies provides all the right answers where and when you need them. Covers the full range of xenobiotics: Includes pharmaceuticals, recreational drugs, and substances of abuse; food and plant toxins; envenomations; household toxins; pesticides and herbicides; rodenticides; metals; poison gases; and environmental toxins Systematically reviews toxicokinetics, pathophysiology, clinical manifestations, diagnostic testing, and management for each xenobiotic Provides "Antidotes in Brief"—at-a-glance guides to specific antidotes and their primary applications Authoritative answers at your fingertips: How to manage the poisoned or overdosed patient What techniques effectively eliminate toxins Which imaging modalities yield the best results
09781260474992
Goldfrank's Clinical Manual of Toxicologic Emergencies, Second Edition
Goldfrank's Clinical Manual of Toxicologic Emergencies, Second Edition

Goldfrank's Clinical Manual of Toxicologic Emergencies, Second Edition, 2nd Edition

ISBN10: 1260474992 | ISBN13: 9781260474992
By Robert Hoffman, Lewis Nelson, Neal Lewin, Mary Howland, Silas W. Smith, Lewis Goldfrank
© 2023

Purchase Options:

* The estimated amount of time this product will be on the market is based on a number of factors, including faculty input to instructional design and the prior revision cycle and updates to academic research-which typically results in a revision cycle ranging from every two to four years for this product. Pricing subject to change at any time.

Additional Product Information:

Derived from the definitive guide to medical toxicology, this hands-on companion provides accurate information for diagnosing and treating poisoned patients on the spot After more than a decade on the market, Goldfrank’s Toxicologic Emergencies has established itself as the go-to reference for medical toxicology—and this companion manual distills the most important information into a portable, easy-to-navigate resource. Goldfrank’s Manual of Toxicologic Emergencies distills critical information into short summaries and synopses, so you can use it to treat patients in clinical settings or for quick review of critical topics. Fully updated to ensure all information is completely current, this new edition is filled with tables, figures, images, and other visuals to make finding the right answers quick and easy. Each chapter is a direct distillation of the corresponding chapter in Goldfrank’s Toxicologic Emergencies. Whether you’re a medical toxicologist, pharmacist, physician, nurse practitioner, or student, Goldfrank’s Manual of Toxicologic Emergencies provides all the right answers where and when you need them. Covers the full range of xenobiotics: Includes pharmaceuticals, recreational drugs, and substances of abuse; food and plant toxins; envenomations; household toxins; pesticides and herbicides; rodenticides; metals; poison gases; and environmental toxins Systematically reviews toxicokinetics, pathophysiology, clinical manifestations, diagnostic testing, and management for each xenobiotic Provides "Antidotes in Brief"—at-a-glance guides to specific antidotes and their primary applications Authoritative answers at your fingertips: How to manage the poisoned or overdosed patient What techniques effectively eliminate toxins Which imaging modalities yield the best results

The table of contents (below) will mirror the main text, both for completeness and ease of cross-referencing.

    Historical Principles and Perspectives

    Toxicologic Misfortunes and Catastrophes in History

    PART A

    THE GENERAL APPROACH TO THE PATIENT

    Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes

    Principles of Managing the Acutely Poisoned or Overdosed Patient

    SC1. Principles of Antidote Stocking

    Decontamination Principles: Prevention of Gastrointestinal Absorption

SC2. Decontamination Principles: Prevention of Dermal, ophthalmic and inhalational Absorption

A1. Activated Charcoal

A2. Whole-Bowel Irrigation and Other Intestinal Evacuants

    Principles and Techniques Applied to Enhance Elimination

    Laboratory Principles

    Principles of Diagnostic Imaging

    Pharmacokinetic and Toxicokinetic Principles

    PART B

    THE FUNDAMENTAL PRINCIPLES OF MEDICALTOXICOLOGY

SECTION I

BIOCHEMICAL AND MOLECULAR CONCEPTS

    Chemical Principles

    Biochemical and Metabolic Principles

    Fluid, Electrolyte, and Acid–Base Principles

    Neurotransmitters and Neuromodulators

    Withdrawal Principles

SECTION II

PATHOPHYSIOLOGIC BASIS: ORGAN SYSTEMS

    Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles

    Cardiologic Principles II: Hemodynamics

    Dermatologic Principles

SC3. Transdermal Toxicology

    Gastrointestinal Principles

    Genitourinary Principles

    Hematologic Principles

    Hepatic Principles

    Neurologic Principles

    Oncologic Principles

    Ophthalmic Principles

    Otolaryngologic Principles

    Psychiatric Principles

    SC4. patient violence

    Respiratory Principles

    Thermoregulatory Principles

SECTION III

SPECIAL POPULATIONS

    Reproductive and Perinatal Principles

    Pediatric Principles

    Geriatric Principles

    PART C

    THE CLINICAL BASIS OF MEDICAL TOXICOLOGY

    SECTION I

    A. ANALGESICS AND ANTIINFLAMMATORY MEDICATIONS

    Acetaminophen

A3. N-Acetylcysteine

    Colchicine, Podophyllin, and the Vinca Alkaloids

    Nonsteroidal Antiinflammatory Drugs

    Opioids

A4. Opioid antagonists

SC5. Internal Concealment of Xenobiotics

SC6. Harm Reduction for Opioid Overdose

    Salicylates

A5. Sodium bicarbonate

B. Food, Diet, and Nutrition

    Botulism

A6. botulinum antitoxin

    Food Poisoning

    Dieting Xenobiotics and Regimens

    Athletic Performance Enhancers

    Essential Oils

    Plantand Animal-Derived Dietary Supplements

    Vitamins

    Iron

A7. deferoxamine


C. pharmaceuticals

    Pharmaceutical Additives

    Antidiabetics and Hypoglycemics/Antiglycemics

A8. Dextrose(d-Glucose)

A9. octreotide

    Antiepileptics

A10. l-carnitine

    Antihistamines and Decongestants

    A11. physostigmine salicylate

    Chemotherapeutics

    Methotrexate,5-Flourouracil, and Capecitabine

A12. folates :leucovorin (Folinic acid) and Folic Acid

A13. glucarpidase(carboxypeptidase g2)

A14. uridine triacetate

SC7. Inadvertent Intrathecal Administration of Xenobiotics

SC8. Extravasation of Chemotherapeutics

    Antimigraine Medications

    Thyroidand Antithyroid Medications

D. Antimicrobials

    Antibacterials, Antifungals, and Antivirals

    Antimalarials

    Antituberculous Medications

A15. pyridoxine

E. Cardiopulmonary Medications

CASE STUDY 4

    Antidysrhythmics

A16. Magnesium Sulfate

    Antithrombotics

A17. Protein Complex Concentrate and Novel Antithrombotic Antidotes

A18. Vitamin k1

A19. protamine

    β-Adrenergic Antagonists

    A20. Glucagon

    Calcium Channel Blockers

    A21. High-dose insulin (HDI)

    Miscellaneous Antihypertensives and Pharmacologically Related Agents

    Cardioactive Steroids

A22. digoxin-specific antibody fragments

    Methylxanthines and Selective β2-Adrenergic Agonists

F.ANESTHETICS AND RELATED MEDICATIONS

    Local Anesthetics

    A23. lipid emulsion

    Inhalational Anesthetics

    Neuromuscular Blockers

    A24. dantrolene sodium

G. Psychotropics

    Antipsychotics

    Cyclic Antidepressants

    Serotonin Reuptake Inhibitors and Atypical Antidepressants

    Lithium

    Monoamine Oxidase Inhibitors

    Sedative-Hypnotics

    A25. flumazenil

H. SUBSTANCES OF ABUSE

    Amphetamines

    Cannabinoids

    Cocaine

    A26. Benzodiazepines

    Ethanol

    A27. Thiamine hydrochloride

    Ethanol Withdrawal

    Disulfiram and Disulfiram-like Reactions

    Hallucinogens

    γ-Hydroxybutyric Acid (γ-Hydroxybutyrate)

    Inhalants

    Nicotine

    Phencyclidine and Ketamine

I. Metals

    Aluminum

    Antimony

    Arsenic

    A28. Dimercaprol (british anti-lewisite or bal)

    Bismuth

    Cadmium

    Cesium

    Chromium

    Cobalt

    Copper

    Lead

    A29. succimer (2,3-dimercaptosuccinic acid)

A30. edetate calcium disodium (CaNa2EDTA)

    Manganese

    Mercury

    Nickel

    Selenium

    Silver

    Thallium

    A31. Prussian blue

    Zinc

J. HOUSEHOLD PRODUCTS

    Antiseptics, Disinfectants, and Sterilants

    Camphorand Moth Repellents

    Caustics

    Hydrofluoric Acid and Fluorides

    A32. Calcium

    Hydrocarbons

    Toxic Alcohols

    A33. fomepizole

    A34. ethanol

    SC9. Diethylene Glycol

K. PESTICIDES

    Barium

    Fumigants

    Herbicides

    Insecticides: Organic Phosphorus Compounds and Carbamates

A35. Atropine

A36. Pralidoxime

    Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, Neonicitinoids and Insect Repellents

    Phosphorus

    Sodium Monofluoroacetate and Fluoroacetamide

    Strychnine

L. Natural Toxins and Envenomations

    Arthropod

    A37. antivenom: spider

    A38. antivenom: scorpion

    Marine Envenomations

    Mushrooms

    Plants

    Native(US) Venomous Snakes and Lizards

    A39. antivenom: snakes (native [US] venomous [crotaline and elapid])

    SC10. Exotic Nonnative Snake Envenomations

M. OCCUPATIONAL AND ENVIRONMENTAL TOXINS

CASE STUDY 11

    Smoke Inhalation

    Simple Asphyxiants and Pulmonary Irritants

    Carbon Monoxide

    A40. hyperbaric oxygen

    Cyanide and Hydrogen Sulfide

A41. hydroxocobalamin

A42. nitrites(sodium amyl) and sodium thiosulfate

    Methemoglobin Inducers

A43. methyleneblue

    Nanotoxicology

N. DISASTER PREPAREDNESS

    Chemical Weapons

    Biological Weapons

    Radiation

    A44. Potassium iodide

A45. Pentetic acid or pentetate (zinc or calcium) trisodium (dtpa)

part D

POPULATION HEALTH

section 1

POISON CENTERS, HEALTH SYSTEMS, AND EPIDEMIOLOGY

    Poison Prevention and Education

    Poison Centers and Poison Epidemiology

    Principles of Occupational Toxicology: Diagnosis and Control

    Hazardous Materials Incident Response

    Risk Assessment and Risk Communication

    Medication Safety and Adverse Drug Events

    Drug Development, Adverse Drug Events, and Post-marketing Surveillance

    International Perspectives on Medical Toxicology

    Principles of Epidemiology and Research Design

    Section II

    LEGAL ASPECTS OF TOXICOLOGY

    Risk Management and Legal Principles

    Medicolegal Interpretive Toxicology

    SC11. Assessment of Ethanol-Induced Impairment

    Postmortem Toxicology

    SC12. Organ Procurement from Poisoned Patients

About the Author

Robert Hoffman

Lewis Nelson

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

Neal Lewin

Mary Howland

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

Silas W. Smith

Lewis Goldfrank

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