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ISBN10: 0071769390 | ISBN13: 9780071769396
ISBN10: 0071769390
ISBN13: 9780071769396
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The landmark text in medical pharmacology is now in full color Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 4 STAR DOODY'S REVIEW! "This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering: General Principles Neuropharmacology Modulation of Cardiovascular Function Inflammation, Immunomodulation, and Hematopoiesis Endocrine Pharmacology Gastrointestinal Pharmacology Chemotherapy of Infectious Disease Chemotherapy of Neoplastic Diseases Special Systems Pharmacology More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.
Contributors
Consultants to the Editors
Preface
Preface to the First Edition
SECTION I: GENERAL PRINCIPLES
1. Drug Invention and the Pharmaceutical Industry, Suzanne M. Rivera and Alfred Goodman Gilman
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination, Iain L. O. Buxton and Leslie Z. Benet
3. Pharmacodynamics: Molecular Mechanisms of Drug Action, Donald K. Blumenthal and James C. Garrison
4. Drug Toxicity and Poisoning, Kevin C. Osterhoudt and Trevor M. Penning
5. Membrane Transporters and Drug Response, Kathleen M. Giacomini and Yuichi Sugiyama
6. Drug Metabolism, Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey
7. Pharmacogenetics, Mary V. Relling and Kathleen M. Giacomini
SECTION II: NEUROPHARMACOLOGY
8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, Thomas C. Westfall and David P. Westfall
9. Muscarinic Receptor Agonists, Joan Heller Brown and Nora Laiken
10. Anticholinesterase Agents, Palmer Taylor
11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Ryan E. Hibbs and Alexander C. Zambon
12. Adrenergic Agonists and Antagonists, Thomas C. Westfall and David P. Westfall
13. 5-Hydroxytryptamine (Serotonin) and Dopamine, Elaine Sanders-Bush and Lisa Hazelwood
14. Neurotransmission and the Central Nervous System, Perry B. Molinoff
15. Drug Therapy of Depression and Anxiety Disorders, James M. O'Donnell and Richard C. Shelton
16. Pharmacotherapy of Psychosis and Mania, Jonathan M. Meyer
17. Hypnotics and Sedatives, S. John Mihic and r. Adron Harris
18. Opioids, Analgesia, and Pain Management, Tony L. Yaksh and Mark S. Wallace
19. General Anesthetics and Therapeutic Gases, Piyush M. Patel, Hemal H. Patel, and David M. Roth
20. Local Anesthetics, William A. Catteral nad Kenneteh Mackie
21. Pharmacotherapy of the Epilepsies, James O. McNamara
22. Treatment of Central Nervous System Degenerative Disorders, David G. Standaert and Erik D. Roberson
23. Ethanol and Methanol, Marc A. Schuckit
24. Drug Addition, Charles P. O'Brien
SECTION III: MODULATION OF CARDIOVASCULAR FUNCTION
25. Regulation of Renal Function and Vascular Volume, Robert F. Reilly and Edwin K. Jackson
26. Renin and Angiotensin, Randa Hilal-Dandan
27. Treatment of Myocardial Ischemia and Hypertension, Thomas Michel and Brian B. Hoffman
28. Pharmacotherapy of Congestive Heart Failure, Bradley A. Maron and Thomas P. Rocco
29. Anti-Arrhythmic Drugs, Kevin J. Sampson and Robert S. Kass
30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs, Jeffrey I. Weitz
31. Drug Therapy for Hypercholesterolemia and Dyslipiedmia, Thomas P. Bersot
SECTION IV: INFLAMMATION, IMMUNOMODULATION, AND HEMATOPOIESIS
32. Histamine, Bradykinin, and Their Antagonists, Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erdös
33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, Emer M. Smyth, Tilo Grosser, and Garret A. Fitzgerald
34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacology of Gout, Tilo Grosser, Emer Smyth, and Garret A. FitzGerald
35. Immunosupressants, Tolerogens, and Immunostimulants, Alan M. Krensky, William M. Bennett, and Flavio Vincenti
36. Pulmonary Pharmacology, Peter J. Barnes
37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Kenneth Kaushansky and Thomas J. Kipps
SECTION V: HORMONES AND HORMONE ANTAGONISTS
38. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Keith L. Parker and Ber
Consultants to the Editors
Preface
Preface to the First Edition
SECTION I: GENERAL PRINCIPLES
1. Drug Invention and the Pharmaceutical Industry, Suzanne M. Rivera and Alfred Goodman Gilman
2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination, Iain L. O. Buxton and Leslie Z. Benet
3. Pharmacodynamics: Molecular Mechanisms of Drug Action, Donald K. Blumenthal and James C. Garrison
4. Drug Toxicity and Poisoning, Kevin C. Osterhoudt and Trevor M. Penning
5. Membrane Transporters and Drug Response, Kathleen M. Giacomini and Yuichi Sugiyama
6. Drug Metabolism, Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey
7. Pharmacogenetics, Mary V. Relling and Kathleen M. Giacomini
SECTION II: NEUROPHARMACOLOGY
8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, Thomas C. Westfall and David P. Westfall
9. Muscarinic Receptor Agonists, Joan Heller Brown and Nora Laiken
10. Anticholinesterase Agents, Palmer Taylor
11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Ryan E. Hibbs and Alexander C. Zambon
12. Adrenergic Agonists and Antagonists, Thomas C. Westfall and David P. Westfall
13. 5-Hydroxytryptamine (Serotonin) and Dopamine, Elaine Sanders-Bush and Lisa Hazelwood
14. Neurotransmission and the Central Nervous System, Perry B. Molinoff
15. Drug Therapy of Depression and Anxiety Disorders, James M. O'Donnell and Richard C. Shelton
16. Pharmacotherapy of Psychosis and Mania, Jonathan M. Meyer
17. Hypnotics and Sedatives, S. John Mihic and r. Adron Harris
18. Opioids, Analgesia, and Pain Management, Tony L. Yaksh and Mark S. Wallace
19. General Anesthetics and Therapeutic Gases, Piyush M. Patel, Hemal H. Patel, and David M. Roth
20. Local Anesthetics, William A. Catteral nad Kenneteh Mackie
21. Pharmacotherapy of the Epilepsies, James O. McNamara
22. Treatment of Central Nervous System Degenerative Disorders, David G. Standaert and Erik D. Roberson
23. Ethanol and Methanol, Marc A. Schuckit
24. Drug Addition, Charles P. O'Brien
SECTION III: MODULATION OF CARDIOVASCULAR FUNCTION
25. Regulation of Renal Function and Vascular Volume, Robert F. Reilly and Edwin K. Jackson
26. Renin and Angiotensin, Randa Hilal-Dandan
27. Treatment of Myocardial Ischemia and Hypertension, Thomas Michel and Brian B. Hoffman
28. Pharmacotherapy of Congestive Heart Failure, Bradley A. Maron and Thomas P. Rocco
29. Anti-Arrhythmic Drugs, Kevin J. Sampson and Robert S. Kass
30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs, Jeffrey I. Weitz
31. Drug Therapy for Hypercholesterolemia and Dyslipiedmia, Thomas P. Bersot
SECTION IV: INFLAMMATION, IMMUNOMODULATION, AND HEMATOPOIESIS
32. Histamine, Bradykinin, and Their Antagonists, Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erdös
33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, Emer M. Smyth, Tilo Grosser, and Garret A. Fitzgerald
34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacology of Gout, Tilo Grosser, Emer Smyth, and Garret A. FitzGerald
35. Immunosupressants, Tolerogens, and Immunostimulants, Alan M. Krensky, William M. Bennett, and Flavio Vincenti
36. Pulmonary Pharmacology, Peter J. Barnes
37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Kenneth Kaushansky and Thomas J. Kipps
SECTION V: HORMONES AND HORMONE ANTAGONISTS
38. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Keith L. Parker and Ber
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