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ISBN10: 1259837947 | ISBN13: 9781259837944
ISBN10: 1259837947
ISBN13: 9781259837944
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Gain a full understanding of the principles of biochemistry as it relates to clinical medicine A Doody’s Core Title for 2021! The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-color presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school. All 58 chapters help you understand the medical relevance of biochemistry: • Full-color presentation includes more than 600 illustrations • Case studies emphasize the clinical relevance of biochemistry • NEW CHAPTER on Biochemistry of Transition Metals addresses the importance and overall pervasiveness of transition metals • Review Questions follow each of the eleven sections • Boxed Objectives define the goals of each chapter • Tables encapsulate important information • Every chapter includes a section on the biomedical importance of a given topic NEW TO THIS EDITION: • Emphasis throughout on the integral relationship between biochemistry and disease, diagnostic pathology, and medical practice • Hundreds of references to disease states throughout • New chapter addressing the biochemical roles of transition metals • Many updated review questions • Frequent tables summarizing key links to disease states • New text on cryo-electron microscopy (cryo-EM) • Cover picture of the protein structure of the Zika virus, solved by cryo-EM Applauded by medical students and online reviewers for its currency and engaging style, Harper’s Illustrated Biochemistry is essential for USMLE® review and the single-best reference for learning the clinical relevance of any biochemistry topic.
Preface
SECTION I Structures & Functions of Proteins & Enzymes
1 Biochemistry & Medicine
2 Water & pH
3 Amino Acids & Peptides
4 Proteins: Determination of Primary Structure
5 Proteins: Higher Orders of Structure
SECTION II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals
6 Proteins: Myoglobin & Hemoglobin
7 Enzymes: Mechanism of Action
8 Enzymes: Kinetics
9 Enzymes: Regulation of Activities
10 The Biochemical Roles of Transition Metals
SECTION III Bioenergetics
11 Bioenergetics: The Role of ATP
12 Biologic Oxidation
13 The Respiratory Chain & Oxidative Phosphorylation
SECTION IV Metabolism of Carbohydrates
14 Overview of Metabolism & the Provision of Metabolic Fuels
15 Carbohydrates of Physiological Significance
16 The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism
17 Glycolysis & the Oxidation of Pyruvate
18 Metabolism of Glycogen
19 Gluconeogenesis & the Control of Blood Glucose
20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism
SECTION V Metabolism of Lipids
21 Lipids of Physiologic Significance
22 Oxidation of Fatty Acids: Ketogenesis
23 Biosynthesis of Fatty Acids & Eicosanoids
24 Metabolism of Acylglycerols & Sphingolipids
25 Lipid Transport & Storage
26 Cholesterol Synthesis, Transport, & Excretion
SECTION VI Metabolism of Proteins & Amino Acids
27 Biosynthesis of the Nutritionally Nonessential Amino Acids
28 Catabolism of Proteins & of Amino Acid Nitrogen
29 Catabolism of the Carbon Skeletons of Amino Acids
30 Conversion of Amino Acids to Specialized Products
31 Porphyrins & Bile Pigments
SECTION VII Structure, Function, & Replication of Informational Macromolecules
32 Nucleotides
33 Metabolism of Purine & Pyrimidine Nucleotides
34 Nucleic Acid Structure & Function
35 DNA Organization, Replication, & Repair
36 RNA Synthesis, Processing, & Modification
37 Protein Synthesis & the Genetic Code
38 Regulation of Gene Expression
39 Molecular Genetics, Recombinant DNA, & Genomic Technology
SECTION VIII Biochemistry of Extracellular & Intracellular Communication
40 Membranes: Structure & Function
41 The Diversity of the Endocrine System
42 Hormone Action & Signal Transduction
SECTION IX Special Topics (A)
43 Nutrition, Digestion, & Absorption
44 Micronutrients: Vitamins & Minerals
45 Free Radicals & Antioxidant Nutrients
46 Glycoproteins
47 Metabolism of Xenobiotics
48 Clinical Biochemistry
SECTION X Special Topics (B)
49 Intracellular Traffic & Sorting of Proteins
50 The Extracellular Matrix
51 Muscle & the Cytoskeleton
52 Plasma Proteins & Immunoglobulins
53 Red Blood Cells
54 White Blood Cells
SECTION XI Special Topics (C)
55 Hemostasis & Thrombosis
56 Cancer: An Overview
57 The Biochemistry of Aging
58 Biochemical Case Histories
The Answer Bank
Index
SECTION I Structures & Functions of Proteins & Enzymes
1 Biochemistry & Medicine
2 Water & pH
3 Amino Acids & Peptides
4 Proteins: Determination of Primary Structure
5 Proteins: Higher Orders of Structure
SECTION II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals
6 Proteins: Myoglobin & Hemoglobin
7 Enzymes: Mechanism of Action
8 Enzymes: Kinetics
9 Enzymes: Regulation of Activities
10 The Biochemical Roles of Transition Metals
SECTION III Bioenergetics
11 Bioenergetics: The Role of ATP
12 Biologic Oxidation
13 The Respiratory Chain & Oxidative Phosphorylation
SECTION IV Metabolism of Carbohydrates
14 Overview of Metabolism & the Provision of Metabolic Fuels
15 Carbohydrates of Physiological Significance
16 The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism
17 Glycolysis & the Oxidation of Pyruvate
18 Metabolism of Glycogen
19 Gluconeogenesis & the Control of Blood Glucose
20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism
SECTION V Metabolism of Lipids
21 Lipids of Physiologic Significance
22 Oxidation of Fatty Acids: Ketogenesis
23 Biosynthesis of Fatty Acids & Eicosanoids
24 Metabolism of Acylglycerols & Sphingolipids
25 Lipid Transport & Storage
26 Cholesterol Synthesis, Transport, & Excretion
SECTION VI Metabolism of Proteins & Amino Acids
27 Biosynthesis of the Nutritionally Nonessential Amino Acids
28 Catabolism of Proteins & of Amino Acid Nitrogen
29 Catabolism of the Carbon Skeletons of Amino Acids
30 Conversion of Amino Acids to Specialized Products
31 Porphyrins & Bile Pigments
SECTION VII Structure, Function, & Replication of Informational Macromolecules
32 Nucleotides
33 Metabolism of Purine & Pyrimidine Nucleotides
34 Nucleic Acid Structure & Function
35 DNA Organization, Replication, & Repair
36 RNA Synthesis, Processing, & Modification
37 Protein Synthesis & the Genetic Code
38 Regulation of Gene Expression
39 Molecular Genetics, Recombinant DNA, & Genomic Technology
SECTION VIII Biochemistry of Extracellular & Intracellular Communication
40 Membranes: Structure & Function
41 The Diversity of the Endocrine System
42 Hormone Action & Signal Transduction
SECTION IX Special Topics (A)
43 Nutrition, Digestion, & Absorption
44 Micronutrients: Vitamins & Minerals
45 Free Radicals & Antioxidant Nutrients
46 Glycoproteins
47 Metabolism of Xenobiotics
48 Clinical Biochemistry
SECTION X Special Topics (B)
49 Intracellular Traffic & Sorting of Proteins
50 The Extracellular Matrix
51 Muscle & the Cytoskeleton
52 Plasma Proteins & Immunoglobulins
53 Red Blood Cells
54 White Blood Cells
SECTION XI Special Topics (C)
55 Hemostasis & Thrombosis
56 Cancer: An Overview
57 The Biochemistry of Aging
58 Biochemical Case Histories
The Answer Bank
Index
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